Sunday, April 25, 2010

Ironic. Dr. Daniel Carlat would like a return to the psychiatry that failed to prevent his mother's suicide.

Fewer than 5% of people who die by suicide have psychiatric medication in their system. There is an under use of these medications, and undertreatment of serious conditions. Among those prescribed medication, there is a high rate of non-adherence. One would like to know more of what happened to Dr. Carlat's mother. The idea that paranoia is treatable with talk therapy is not viable. One may also consider suicidality as a form of delusion, a belief that death will solve one's problems and that one will never enjoy life again. For those reasons, one hopes that she was prescribed a neuroleptic tranquilizer, and that she continued to take it. This useful technical information is not provided.


“So Dr. Freud, the causes are all in the brain? Isn’t there some explanation in my childhood?” It was a good-natured tease.

“I specialize in prescribing medications,” I said with a smile. I was a psychopharmacologist and specialized in medication rather than psychotherapy. “I can refer you to a good therapist in the area if you’d like.”

After J.J. left my office, I realized, uncomfortably, that somehow, over the course of the decade following my residency, my way of thinking about patients had veered away from psychological curiosity. Instead, I had come to focus on symptoms, as if they were objective medical findings, much the way internists view blood-pressure readings or potassium levels. Psychiatry, for me and many of my colleagues, had become a process of corralling patients’ symptoms into labels and finding a drug to match.

Leon Eisenberg, an early pioneer in psychopharmacology at Harvard, once made the notable historical observation that “in the first half of the 20th century, American psychiatry was virtually ‘brainless.’ . . . In the second half of the 20th century, psychiatry became virtually ‘mindless.’ ” The brainless period was a reference to psychiatry’s early infatuation with psychoanalysis; the mindless period, to our current love affair with pills. J.J., I saw, had inadvertently highlighted a glaring deficiency in much of modern psychiatry. Ultimately, his question would change the way I thought about my field, and how I practiced.

I originally became interested in psychiatry primarily because of my father: he is a psychiatrist practicing in San Francisco. But there was a darker side to my career choice. My mother suffered severe mental illness, with debilitating depressions and paranoid thoughts. One autumn day during my junior year in college, she committed suicide. Psychiatry then became personal, a way for me to come to terms with her illness.

7 comments:

  1. "Fewer than 5% of people who die by suicide have psychiatric medication in their system." I'd like to have the reference for that statistic. I don't believe it for one second. I have been following the suicides in my surrounding community for several years and in a substantial number where the information was obtainable the victim had been treated. In others we simply don't know for sure -- that doesn't mean they were not on something. You can also go to www.ssristories.com to see a sortable database of nearly 4000 media stories of people committing suicide, murder, murder-suicide or other violent and bizarre acts while medicated. As a doctor it is sheer hubris to underestimate the power of psychiatric medications to harm. If Dr. C himself doesn't know what treatment his mother was getting I think you are going out on a limb to say she was being treated with "old psychiatry," i.e. mainly with talking and listening and perhaps without medication. That is your assumption and not based on any evidence whatsoever.

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  2. Selective serotonin reuptake inhibitor antidepressants and the risk of suicide: a controlled forensic database study of 14,857 suicides. Acta Psychiatr Scand. 2005;111(4):286-290.

    Antidepressants and youth suicide in New York City, 1999-2002. J Am Acad Child Adolesc Psychiatry. 2006;45(9):1054-1058.

    Most suicides may have seen a family doctor the year prior to their deaths, but often for a physical complaint.

    I saw no blood levels of anti-depressants in your list of anecdotes of people who got violent. If tens of millions of people are prescribed a class of medication, I am sure a longer list of violent acts can be compiled from those taking Tylenols for a headache.

    Dr. Carlat's mother may have stopped her medication without telling anyone, as paranoid people often do. She was the wife of a psychiatrist. Presumably, he obtained for her everything psychiatry had to offer. However, this is an assumption, and members of the profession and their family members are indulged, and can often get substandard care.

    Dr. Carlat should get the results of her autopsy and her psychiatric records, if only to bring closure to his family. Doing psychotherapy with paranoid patients is like believing in Santa Claus, except it is not cute.

    I have also proposed that all suicidal people be placed on tranquilizers, not necessarily on anti-depressants. Suicidal urges appear to be familial, and transmitted independently from depression.

    Everyone has seen the social component. A nasty remark from a boyfriend can be more powerful than weeks of anti-depressant treatment, but only in those on the edge already.

    The best verbal advice is to the family as well as to the patient. Tell people about your urges to kill yourself, and cooperate with their eyesight supervision. Poking one's psychotherapy finger into prior psychic wounds with the very suicidal patient is likely to result in a lot of stress responses, and potentially, in the hastening of the demise.

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  3. Isacsson G, Holmgren P, Ahlner J. Selective serotonin reuptake inhibitor antidepressants and the risk of suicide: a controlled forensic database study of 14,857 suicides. Acta Psychiatr Scand. 2005;111(4):286-290.

    Leon AC, Marzuk PM, Tardiff K, Bucciarelli A, Markham Piper T, Galea S. Antidepressants and youth suicide in New York City, 1999-2002. J Am Acad Child Adolesc Psychiatry. 2006;45(9):1054-1058.

    Most suicide victims may have seen a family doctor the year prior to their deaths, but often for a physical complaint.

    No blood levels of anti-depressants in the list of anecdotes of people who got violent. No evidence they were on these at the time of the incident. If a drug is given to tens of millions of people, a small number will get violent, including Tylenol for headaches.

    Dr. Carlat's mother may have stopped her medication without telling anyone, as paranoid people often do. She was the wife of a psychiatrist. Presumably, he obtained for her what psychiatry had to offer. However, this is an assumption, and members of the profession and their family members are indulged, and can often get substandard care. Dr. Carlat should get the results of her autopsy and her psychiatric records, if only to bring closure. Doing psychotherapy with paranoid patients is like believing in Santa Claus, except it is not cute.

    I have also proposed that all suicidal people be placed on tranquilizers, not necessarily on anti-depressants. Suicidal urges appear to be familial, and transmitted independently from depression. Everyone has seen the social component. A nasty remark from a boyfriend can be more powerful than weeks of anti-depressant treatment, but only in those on the edge already.

    The best verbal advice is to the family as well as to the patient. Tell people about your urges to kill yourself, and cooperate with their eyesight supervision. Poking one's psychotherapy finger into prior psychic wounds with the very suicidal patient is likely to result in a lot of stress responses, and in greater risk.

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  4. Here are two aticles that contradict the 5% figure for people taking antidepressants who commit suicide. Remember, too, that antidepressant withdrawal is an extemely dangerous time for suicide because of the extra receptors the body has added to the brain to adjust for the flow of serotonin, etc. into the receptors. When the antidepressant is discontinued, these additional receptors cause an 'overflow' of the neutrotransmitters, especially serotonin, into the receptor sites. This is why SSRI Stories has a prominent warning at the top of the cover page regarding withdrawal.

    http://www.ssristories.com/show.php?item=3523

    Paragraph three reads: "We first looked at antidepressant prescriptions. Of the 776 Scandinavian men in the sample, 259 (32%) (age-adjusted 95% confidence interval [CI]=28.5–35.2) filled a prescription for antidepressants in the 180 days before death. The corresponding figures were 176 of the 333 Scandinavian women in the sample (52%) (CI=46.7–57.5), 32 of the 102 foreign-born men (31%) (CI=21.6–39.5), and 21 of the 44 foreign-born women (43%) (CI=28.7–58.1)."

    http://ps.psychiatryonline.org/cgi/content/full/59/1/116-a

    Psychiatr Serv 59:116-a-117, January 2008
    doi: 10.1176/appi.ps.59.1.116-a
    © 2008 American Psychiatric Association

    Letter

    Ethnic Differences in Antidepressant Treatment Preceding Suicide in Sweden

    ------------------------------------------------------------------------------
    http://www.ssristories.com/show.php?item=3609

    Second paragraph from the end reads: "Of the 17 deaths in the first half of 2009, seven people were taking antidepressant medication, but only one was seeing a counselor. Chappell and Groves said studies show doing both works best."

    SSRI Stories note: Forty-one percent of the people who committed suicide were taking an antidepressant.

    http://www.courierpress.com/news/2009/sep/07/economy-related-suicides-up/

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  5. You sound like a disciple of E. Fuller Torrey and an advocate of forced medication and compliance. If compliance is so critical to preventing suicide maybe you should give some consideration to the effects of chemical dependency and withdrawal that often puts a patient through worse hell than whatever presenting symptoms they originally had. (Not that a tranquilizer here and there might not be life-saving in a crisis situation.)

    I'm surprised you didn't tell me to go out and get a database of people eating Twinkies (rather than Tylenol) who then went on to kill themselves or others. Those who use these arguments to dismiss the value of the database I cite or the suicidal and homicidal effects of antidepressants (and other psych drugs including your beloved tranquilizers) have their head in the sand and are not paying attention to the mountain of evidence that these drugs increase suicidality, in the case of Paxil often by as much as 800 %. There is something drastically amiss in clinical practice if there exists this number of stories of treated people doing such awful things.

    Toxicology analyses by coroners are notoriously incomplete. They are designed to detect illegal drugs, not prescription medications. Unless there is evidence that toxicology was done with the specific purpose of detecting an antidepressant the epidemiology studies you cite are not worth anything. Furthermore withdrawal effects, even long after the drugs are out of the bloodstream, can cause bizarre and destructive behavioral changes due to the effects of the drugs on the brain. It takes months for the brain to re-establish its own allostatic load setting mechanism after a course of treatment with antidepressants or other psych meds. So to rule out the effect of a psych med on a particular outcome one needs not only a complete toxicology analysis but also a medical history. The statistic you cite is bound to be way below what a proper analysis would really show.

    With your attitude towards learning what's really going on in the brain when someone takes these drugs or what the long term effects really are, I would not want to be one of your patients. And I still believe that empathy is a much stronger tool to prevent suicide in most cases than pill popping.

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  6. Sara: Your database is propaganda because it is missing a denominator. You have to compare fractions, not absolute numbers.

    Most suicide victims have not responded to empathy, nor to psychotherapy. Young females have some response to supportive conversations. However, they have the lowest rates of completing suicide of any population group save children.

    Compulsory treatment resulted in the most successful suicide prevention program in history.

    http://afspp.afms.mil/idc/groups/public/documents/webcontent/knowledgejunction.hcst?functionalarea=AFSuicidePreventionPrgm&doctype=subpage&docname=CTB_018094&incbanner=0

    These folks were coerced into ordinary treatments of various types, including medications. As a side benefit, they also caused a big drop in the murder rate.

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  7. Zach: People may have filled their prescriptions for anti-depressants in Scandinavia. How many had some in their bodies at the time of death? An effect is well known for the past 50 years, that as people improve, energy may return before the end of a depressed or hopeless mood. That allows the depressed patient to act on suicidal urges.

    I do not know if you count this as counseling, but advising the patient of the falseness of his suicidal urges, of the sequence of effects of treatment, and asking the family to provide greater eyesight supervision usually prevents most of the events that concern you. Endless rehashing of the past, with passive listening, i.e. the psychodynamic approaches Dr. Carlat may have in mind, explaining behavior by fictitious mental mechanisms, is irresponsible in the face of the potential for such a hard outcome as suicide.

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